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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherBeginnerMedium Risk

Clomiphene Citrate

Also known as: Clomid, Clomifene

Clomiphene citrate is a SERM originally developed for female ovulation induction and widely adopted in PCT protocols and off-label male hypogonadism treatment. It is a racemic mixture of two geometric isomers, enclomiphene (trans) and zuclomiphene (cis), with differing estrogenic properties.

Evidence85/100 — Strong

Risk Level

Medium Risk

Difficulty

Beginner
CAS Number50-41-9
Molecular FormulaC26H28ClNO·C6H8O7
ClassOther
CategorySERMs & AIs

Mechanism of Action

Clomiphene blocks estrogen receptors at the hypothalamus, reducing negative feedback and causing increased pulsatile GnRH release. This leads to elevated LH and FSH secretion from the pituitary, stimulating gonadal function. The enclomiphene isomer is primarily anti-estrogenic while zuclomiphene has more estrogenic activity, giving the racemic mixture a complex pharmacological profile.

Dosing Research

Female fertility: 50-150 mg/day on cycle days 3-7 or 5-9. Male hypogonadism (off-label): 25-50 mg/day or every other day. PCT protocols: 50-100 mg/day for 4-6 weeks, often starting higher and tapering. Half-life is approximately 5 days, though zuclomiphene may persist for weeks.

Side Effects & Risks

Visual disturbances (blurred vision, floaters, scotomata) affect 1-2% of users and are a signal to discontinue. Mood swings, emotional lability, and irritability are common. Hot flashes, headaches, and GI discomfort. Ovarian hyperstimulation in females. Long-term use in males may elevate estradiol due to zuclomiphene accumulation.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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