Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
RAD-140
Also known as: Testolone
RAD-140 is a potent non-steroidal SARM developed by Radius Health. It has shown neuroprotective properties in preclinical studies and is currently in early clinical trials for breast cancer.
Risk Level
High RiskDifficulty
Intermediate| CAS Number | 1182367-47-0 |
| Molecular Formula | C20H16ClN5O2 |
| Class | SARM |
| Category | SARMs |
Mechanism of Action
RAD-140 is a potent and selective androgen receptor agonist in muscle and bone. Preclinical data suggests it crosses the blood-brain barrier and may offer neuroprotective effects. It acts as a competitive antagonist to testosterone in prostate tissue.
Dosing Research
Preclinical studies used 0.01-1 mg/kg in primates. Research community references 10-20 mg/day. Half-life approximately 60 hours. Cycles typically 8 weeks.
Side Effects & Risks
Significant hormonal suppression. Cases of drug-induced liver injury reported in case studies. Potential cardiovascular strain. Limited human safety data — most evidence is preclinical.
Research Studies
Related compounds
Ostarine
SARMOstarine is the most widely studied SARM, originally developed for muscle wasting and osteoporosis. It has completed multiple Phase II and Phase III clinical trials, making it one of the few SARMs with substantial human data.
Ligandrol
SARMLigandrol is a non-steroidal SARM developed by Ligand Pharmaceuticals for muscle wasting conditions. It demonstrated significant lean mass gains in Phase I trials at doses as low as 1 mg/day.
Cardarine
OtherCardarine is not actually a SARM but a PPARδ agonist, often grouped with SARMs commercially. It was developed by GlaxoSmithKline for metabolic and cardiovascular diseases but was abandoned due to cancer findings in rodent studies.
Andarine
SARMAndarine was one of the first SARMs developed by GTx Inc. It showed promise for muscle wasting and osteoporosis in preclinical trials but development was halted due to visual side effects.
Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.