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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherAdvancedMedium Risk

AICAR

Also known as: AICA Ribonucleotide, Acadesine

AICAR is an AMP-activated protein kinase (AMPK) activator that has been called an 'exercise in a pill.' Originally studied for cardiac ischemia, it gained attention for dramatically improving endurance in sedentary mice.

Evidence55/100 — Moderate

Risk Level

Medium Risk

Difficulty

Advanced
CAS Number2627-69-2
Molecular FormulaC9H14N4O5
ClassOther
CategoryOther Performance Compounds

Mechanism of Action

AICAR is taken up by cells and converted to ZMP, which mimics AMP and activates AMPK. AMPK activation triggers pathways normally activated by exercise: increased glucose uptake, enhanced fatty acid oxidation, mitochondrial biogenesis, and improved insulin sensitivity.

Dosing Research

Clinical trials for cardiac ischemia used IV infusions of 0.1 mg/kg/min. Research community references 150-500 mg via injection. Extremely expensive. Poor oral bioavailability. Half-life approximately 90 minutes.

Side Effects & Risks

Hypoglycemia risk due to increased glucose uptake. Potential lactic acidosis. Heart rate changes. Very expensive limiting practical use. WADA banned substance. Limited long-term safety data at performance doses.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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