Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
AICAR
Also known as: AICA Ribonucleotide, Acadesine
AICAR is an AMP-activated protein kinase (AMPK) activator that has been called an 'exercise in a pill.' Originally studied for cardiac ischemia, it gained attention for dramatically improving endurance in sedentary mice.
Risk Level
Medium RiskDifficulty
Advanced| CAS Number | 2627-69-2 |
| Molecular Formula | C9H14N4O5 |
| Class | Other |
| Category | Other Performance Compounds |
Mechanism of Action
AICAR is taken up by cells and converted to ZMP, which mimics AMP and activates AMPK. AMPK activation triggers pathways normally activated by exercise: increased glucose uptake, enhanced fatty acid oxidation, mitochondrial biogenesis, and improved insulin sensitivity.
Dosing Research
Clinical trials for cardiac ischemia used IV infusions of 0.1 mg/kg/min. Research community references 150-500 mg via injection. Extremely expensive. Poor oral bioavailability. Half-life approximately 90 minutes.
Side Effects & Risks
Hypoglycemia risk due to increased glucose uptake. Potential lactic acidosis. Heart rate changes. Very expensive limiting practical use. WADA banned substance. Limited long-term safety data at performance doses.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.