Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Armodafinil
Also known as: Nuvigil, Waklert, Artvigil
Armodafinil is the R-enantiomer of modafinil, providing a longer-lasting and more sustained wakefulness effect. It was developed to offer a cleaner pharmacokinetic profile with higher plasma concentrations later in the day compared to racemic modafinil.
Risk Level
Low RiskDifficulty
Beginner| CAS Number | 112111-43-0 |
| Molecular Formula | C15H15NO2S |
| Class | Other |
| Category | Nootropics |
Mechanism of Action
Armodafinil shares the same mechanism as modafinil — primarily dopamine reuptake inhibition via DAT binding — but as the isolated R-enantiomer, it has a longer effective half-life and more sustained plasma levels. It maintains wakefulness-promoting effects through histaminergic and orexinergic pathways without the shorter-acting S-enantiomer.
Dosing Research
Standard dose: 150 mg once daily in the morning (roughly equivalent to 200 mg modafinil). Available as 50, 150, 200, and 250 mg tablets. Half-life approximately 15 hours. Peak plasma concentration reached in 2 hours. Lower doses (50-150 mg) often sufficient for cognitive enhancement.
Side Effects & Risks
Similar profile to modafinil: headache, nausea, dizziness, insomnia. May cause more sustained insomnia than modafinil due to longer half-life. Same rare SJS risk. Appetite suppression common. Can interact with CYP3A4 substrates including hormonal contraceptives.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.