Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Enclomiphene
Also known as: Androxal, trans-Clomiphene
Enclomiphene is the trans-isomer of clomiphene citrate, isolated as the purely anti-estrogenic component. It was developed for secondary hypogonadism in men, raising testosterone while preserving fertility, without the estrogenic side effects of the zuclomiphene isomer found in Clomid.
Risk Level
Low RiskDifficulty
Beginner| CAS Number | 15690-57-0 |
| Molecular Formula | C26H28ClNO |
| Class | Other |
| Category | SERMs & AIs |
Mechanism of Action
Enclomiphene selectively antagonizes estrogen receptors at the hypothalamus and pituitary, blocking negative feedback and increasing LH and FSH release. Unlike racemic clomiphene, it lacks the estrogenic zuclomiphene isomer, resulting in a cleaner anti-estrogenic profile. This leads to sustained testosterone elevation without estrogen receptor agonism in peripheral tissues.
Dosing Research
Clinical trials used 12.5-25 mg/day orally for male secondary hypogonadism. Most research community protocols mirror this at 6.25-25 mg/day. Half-life is approximately 10 hours, significantly shorter than zuclomiphene. Daily dosing is standard due to the shorter half-life.
Side Effects & Risks
Generally well-tolerated with fewer side effects than racemic clomiphene. Headache, nausea, and fatigue reported in clinical trials. Lower incidence of visual disturbances and emotional side effects compared to Clomid. Not yet FDA-approved; long-term safety data is limited.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.