Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Fisetin
Fisetin is a flavonoid found in strawberries, apples, and other fruits. It has emerged as one of the most potent natural senolytic compounds, selectively killing senescent (zombie) cells that accumulate with age and drive chronic inflammation and tissue dysfunction. Mayo Clinic research has shown it extends lifespan in aged mice.
Risk Level
Low RiskDifficulty
Beginner| CAS Number | 528-48-3 |
| Molecular Formula | C15H10O6 |
| Class | Other |
| Category | Longevity Compounds |
Mechanism of Action
Fisetin induces apoptosis selectively in senescent cells by inhibiting pro-survival pathways including PI3K/AKT and BCL-2 family members. It also activates AMPK and sirtuins, reduces mTOR signaling, and has potent anti-inflammatory and antioxidant properties. As a senolytic, it clears SASP-producing senescent cells, reducing the pro-inflammatory secretome that drives age-related tissue dysfunction.
Dosing Research
Senolytic protocol (Mayo Clinic inspired): 20 mg/kg bodyweight for 2 consecutive days, repeated monthly. This works out to roughly 1000-1500 mg/day for 2 days per month. Daily low-dose: 100-500 mg/day as an anti-inflammatory. Bioavailability is poor; lipid-based formulations may help. Often combined with quercetin.
Side Effects & Risks
Very well-tolerated in available data. Minor GI discomfort possible. Very low toxicity in animal studies. Limited human clinical data (trials ongoing at Mayo Clinic). Poor bioavailability is the main limitation. No significant drug interactions documented at typical doses.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.