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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherBeginnerLow Risk

Modafinil

Also known as: Provigil, Modalert, Modvigil

Modafinil is a eugeroic (wakefulness-promoting) agent originally developed for narcolepsy, now widely used off-label as a cognitive enhancer. It is one of the most well-studied and commonly used nootropics, with robust evidence supporting improvements in attention, executive function, and wakefulness in sleep-deprived individuals.

Evidence78/100 — Strong

Risk Level

Low Risk

Difficulty

Beginner
CAS Number68693-11-8
Molecular FormulaC15H15NO2S
ClassOther
CategoryNootropics

Mechanism of Action

Modafinil's exact mechanism is not fully understood but involves inhibition of dopamine reuptake via DAT binding, increased histamine and orexin signaling in the hypothalamus, and modulation of GABA/glutamate balance. Unlike amphetamines, it produces wakefulness without significant peripheral sympathomimetic effects or euphoria at standard doses.

Dosing Research

Standard dose: 100-200 mg taken once in the morning. Some users split into 100 mg morning and 100 mg early afternoon. Half-life is 12-15 hours. Onset within 30-60 minutes. Food may delay but does not reduce absorption. Tolerance can develop with daily use.

Side Effects & Risks

Common: headache, nausea, anxiety, insomnia if taken too late in the day. Less common: elevated heart rate, dry mouth, appetite suppression. Rare but serious: Stevens-Johnson syndrome (SJS) — discontinue immediately if rash develops. May reduce effectiveness of hormonal contraceptives.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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