Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
NR (Nicotinamide Riboside)
Also known as: NR, Niagen, Nicotinamide Riboside
Nicotinamide Riboside (NR) is a form of vitamin B3 that serves as an NAD+ precursor. It was the first commercially available NAD+ booster and has more human clinical trial data than NMN. Sold as Niagen by ChromaDex, it has demonstrated ability to raise blood NAD+ levels in multiple human studies.
Risk Level
Low RiskDifficulty
Beginner| CAS Number | 1341-23-7 |
| Molecular Formula | C11H15N2O5 |
| Class | Other |
| Category | Longevity Compounds |
Mechanism of Action
NR enters cells via equilibrative nucleoside transporters and is phosphorylated by NR kinases (NRK1/2) to form NMN, which is then converted to NAD+ by NMNAT enzymes. This pathway bypasses the rate-limiting step of the salvage pathway. Elevated NAD+ activates sirtuins and supports PARP-mediated DNA repair, mitochondrial biogenesis, and cellular energy metabolism.
Dosing Research
Standard dose: 300-1000 mg/day orally. Clinical trials have used 100-2000 mg/day. Typically taken once daily in the morning. ChromaDex Niagen recommends 300 mg/day. Higher doses (1000+ mg) have shown safe in clinical studies. No cycling typically required.
Side Effects & Risks
Well-tolerated in clinical trials up to 2000 mg/day. Mild nausea, fatigue, headache, and diarrhea reported by a small percentage. Similar theoretical cancer concern as NMN (no human evidence). Flushing is rare (unlike niacin). Good safety profile based on multiple human studies.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.