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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherIntermediateLow Risk

Pramiracetam

Also known as: Pramistar, Remen

Pramiracetam is one of the most potent racetams by weight, estimated to be 5-10 times stronger than piracetam. It is primarily used for memory enhancement and focused cognitive work, and has been studied for its ability to reverse amnesia induced by scopolamine in human trials.

Evidence40/100 — Emerging

Risk Level

Low Risk

Difficulty

Intermediate
CAS Number68497-62-1
Molecular FormulaC14H27N3O2
ClassOther
CategoryNootropics

Mechanism of Action

Pramiracetam's primary mechanism involves stimulation of high-affinity choline uptake (HACU) in the hippocampus, thereby increasing acetylcholine synthesis. Unlike other racetams, it has minimal direct effect on other neurotransmitter systems. It also modulates nitric oxide synthase activity and enhances cerebral blood flow. Its focused cholinergic action may explain its reputation for 'pure' cognitive enhancement without mood effects.

Dosing Research

Typical dose: 400-1200 mg/day divided into 2-3 doses. Most common protocol is 400 mg three times daily. Fat-soluble — take with meals containing fat. Half-life approximately 5-6 hours. Has a notably bitter taste in powder form. Capsules preferred for palatability.

Side Effects & Risks

Generally well-tolerated. Headache (choline supplementation recommended), GI discomfort, jaw tension. Emotional blunting reported by some users due to its 'clinical' cognitive effect. No known serious adverse effects or dependency potential. Extremely bitter taste may cause nausea if taken as powder.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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