Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Rapamycin
Also known as: Sirolimus, Rapamune
Rapamycin is an mTOR inhibitor originally developed as an immunosuppressant for organ transplant recipients. It has emerged as one of the most promising longevity compounds, consistently extending lifespan in multiple animal models including mice, even when started late in life. It is increasingly used off-label by longevity-focused physicians.
Risk Level
Medium RiskDifficulty
Advanced| CAS Number | 53123-88-9 |
| Molecular Formula | C51H79NO13 |
| Class | Other |
| Category | Longevity Compounds |
Mechanism of Action
Rapamycin inhibits mTOR complex 1 (mTORC1), a master regulator of cell growth, protein synthesis, and metabolism. Inhibiting mTORC1 upregulates autophagy, reduces senescent cell accumulation, improves stem cell function, and shifts metabolism toward a more youthful state. Intermittent dosing selectively inhibits mTORC1 while sparing mTORC2 (which mediates immunosuppressive side effects).
Dosing Research
Longevity protocols typically use 3-6 mg once weekly (intermittent dosing), far below the daily immunosuppressive dose of 2-5 mg/day. Some protocols use 1-2 mg every 2 weeks. Blood trough levels can be monitored to stay in the 2-5 ng/mL range. Often cycled with periodic breaks. Always under physician supervision.
Side Effects & Risks
Mouth ulcers/canker sores (most common at longevity doses), mildly elevated blood glucose and lipids, impaired wound healing. At immunosuppressive doses: increased infection risk, pneumonitis, thrombocytopenia. Intermittent low-dose protocols appear to avoid most serious side effects. Paradoxically may enhance some immune functions at low doses.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.