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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.
Spermidine
Spermidine is a naturally occurring polyamine found in aged cheese, wheat germ, soy, and mushrooms. It is a potent inducer of autophagy and has been shown to extend lifespan in yeast, flies, worms, and mice. Epidemiological studies associate higher dietary spermidine intake with reduced cardiovascular and all-cause mortality in humans.
Risk Level
Low RiskDifficulty
Beginner| CAS Number | 124-20-9 |
| Molecular Formula | C7H19N3 |
| Class | Other |
| Category | Longevity Compounds |
Mechanism of Action
Spermidine induces autophagy by inhibiting the acetyltransferase EP300 (p300), leading to hypoacetylation of multiple autophagy-related proteins including Beclin-1 and LC3. This triggers autophagic flux, promoting clearance of damaged organelles and protein aggregates. It also has anti-inflammatory effects, improves mitochondrial function, and may enhance stem cell renewal. Endogenous spermidine levels decline with age.
Dosing Research
Supplement dose: 1-6 mg/day orally. Wheat germ extract is the most common supplement form (providing approximately 1-2 mg spermidine per serving). Clinical trials have used 1.2-3.3 mg/day. Can also be increased through diet (aged cheese, wheat germ, natto, mushrooms). No cycling required.
Side Effects & Risks
Very well-tolerated. Spermidine is a normal component of diet and endogenous metabolism. Minor GI discomfort possible with supplements. No significant adverse effects reported in clinical studies. Safe enough to be obtained from normal dietary sources. Long-term supplementation safety data still accumulating.
Research Studies
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Disclaimer
CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.