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CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

OtherIntermediateMedium Risk

SR9009

Also known as: Stenabolic

SR9009 is a synthetic Rev-ErbA agonist developed at Scripps Research Institute. It affects circadian rhythm biology and has shown dramatic effects on metabolism and endurance in mouse studies.

Evidence38/100 — Emerging

Risk Level

Medium Risk

Difficulty

Intermediate
CAS Number1379686-30-2
Molecular FormulaC20H24ClN3O4S
ClassOther
CategoryOther Performance Compounds

Mechanism of Action

SR9009 activates Rev-Erbα, a nuclear receptor that plays a key role in circadian rhythm regulation. This activation increases mitochondrial count in muscle, enhances fatty acid and glucose oxidation, and decreases fat storage. It essentially mimics the effects of exercise at the cellular level.

Dosing Research

Animal studies used 100 mg/kg in mice. Oral bioavailability is extremely poor (~2%). Research community references 20-30 mg/day, often split into 3-4 doses due to short half-life of 4 hours. Sublingual administration sometimes used.

Side Effects & Risks

Very poor oral bioavailability limits effectiveness. Potential circadian rhythm disruption. Insomnia if taken too late in the day. Limited human data. Liver metabolism concerns with frequent dosing.

Research Studies

Disclaimer

CompoundIQ publishes research summaries for informational and educational purposes only. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. Always consult a licensed healthcare provider. Many compounds listed are research chemicals not approved for human use.

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